Intraocular pressure predicts premature coronary atherosclerosis

Mehmet Kaplan¹, Ozge Ozcan Abacýoglu², Fethi Yavuz², Gizem Ilgýn Kaplan³, Betül Düzen⁴, Nurbanu Bursa⁵, Ferhat Zorlu⁶

早期アテローム性動脈硬化症(PACAD)と中心角膜の厚さ(ＣＣＴ)・眼圧(ＩＯＰ)の関連を調査。

ＰＡＣＡＤ患者100名とアテローム動脈硬化のない対照86名を比較

患者背景；

TABLE 1 BASELINE DEMOGRAPHIC CHARACTERISTICS AND BIOCHEMICAL VARIABLES OF THE GROUPS

Demographic properties	PACAD (n=100)	Control (n=86)	p value
Age (years, mean)	34.7 ±4.5	34.3 ±7.5	0.860
Sex (female, %)	48 (48 %)	48 (56 %)	0.290
Hypertension (n, %)	20 (20 %)	24 (28 %)	0.206
Diabetes Mellitus (n, %)	19 (19 %)	19 (22 %)	0.602
Smoking (n, %)	35 (35 %)	16 (19 %)	0.012 *
Hypercholesterolemia (n, %)	48 (48%)	22 (25 %)	0.042 *
Family history for CAD (n, %)	36 (36 %)	24 (28 %)	0.386
Metabolic syndrome (n, %)	17 (17 %)	14 (16 %)	0.752
Biochemical variables
Hemoglobin (g/dL)	12.9±1.7	12.8±0.9	0.438
Leukocyte (×10³ /μL)	8.7 ±1.7	10.4±3.3	0.086
Platelet (×10³ /μL)	309±90	346±315	0.600
Plasma fasting glucose (mg/dL)	84±11	87±11	0.403
Creatinine (mg/dL)	0.63±0.18	0.64±0.14	0.466
LDL-C (mg/dL)	109±30	110±28	0.727
HDL-C (mg/dL)	44±11	44±8	0.887
BNP (pg/mL)	43±16	37±19	0.853
High sensitivity CRP (mg/L)	1.3±0.6	1.0±0.7	0.063

Abbreviations: CA, coronary artery disease; LDL-C, low-density lipoprotein-cholesterol; HDL-C, high-density lipoprotein-cholesterol; BNP, brain natriuretic peptide.

^*p<0.05 is significant.

その結果、

ＰＡＣＡＤはコントロールに比べ、

中心角膜の厚さに差はなく、眼圧が高い。

脈波伝播速度(ＰＷＶ)も有意差があった。

TABLE 2 OPHTHALMOLOGICAL AND CARDIOLOGIC EXAMINATION FINDINGS OF THE GROUPS

Ophthalmological examination	PACAD (n=100)	Control (n=86)	p-value
Intraocular pressure (mm Hg)	14.4 ±4.5	13.0±1.0	0.000 *
Central corneal thickness (μm)	537±14	535±19	0.800
Ocular hypertension (n, %)	3 (%3)	1 (%1.5)	0.242
Cardiologic examination
Ejection Fraction (%)	62.6±3	61.4±4	0.043 *
Pulse wave velocity (m/s)	6 ±1.1	5.5±0.7	0.001 *