口内炎とビタミンサプリ

Randomized Controlled Trial

 

J Am Dent Assoc

 

. 2012 Apr;143(4):370-6.

 doi: 10.14219/jada.archive.2012.0179.

Multivitamin therapy for recurrent aphthous stomatitis: a randomized, double-masked, placebo-controlled trial

Rajesh V Lalla ¹, Linda E Choquette, Richard S Feinn, Harriet Zawistowski, Marie C Latortue, Edward T Kelly, Lorena Baccaglini

 

マルチビタミンは再発性アフタ性口内炎を改善するか？

 

研究デザイン；ダブルブラインドRCT

 

160名の対象者を、

マルチビタミンを摂取するグループ83名

プラセボを摂取するグループ77名

に割り付け。

 

口内炎の再発数；

マルチビタミン4.19

プラセボ4.60

と有意差なし。

TABLE 2

Incidence of recurrent aphthous stomatitis episodes, according to treatment arm and stratification group.

GROUP	MEAN (SD*) NUMBER OF NEW EPISODES	NUMBER OF PARTICIPANTS
Placebo
A†	1.92 (2.99)	13
B‡	5.14 (4.67)	64
TOTAL	4.60 (4.58)	77
Multivitamin
A	3.00 (4.29)	15
B	4.46 (4.82)	68
TOTAL	4.19 (4.74)	83
Placebo and Multivitamin Arms Combined
A	2.50 (3.72)	28
B	4.79 (4.75)	132
TOTAL	4.39 (4.65)	160

^*SD: Standard deviation.

^†Group A: Three to four episodes of minor recurrent aphthous stomatitis reported in previous year.

^‡Group B: Five or more episodes of minor recurrent aphthous stomatitis reported in previous year.

 

再発してからの期間；

マルチビタミン8.66日

プラセボ8.99日

と有意差なし。

Duration of recurrent aphthous stomatitis (RAS) episodes.

TREATMENT ARM	MEAN (SD*) DURATION IN DAYS	NUMBER OF PARTICIPANTS	NUMBER OF EPISODES
Placebo	8.99 (5.22)	63†	329
Multivitamin	8.66 (4.60)	61‡	335
Placebo and Multivitamin Arms Combined	8.83 (4.92)	124	664

^*SD: Standard deviation.

^†Fourteen participants in the placebo arm were excluded from the duration analysis because they did not experience any new RAS episodes during study participation.

^‡Twenty-two participants in the multivitamin arm were excluded from the duration analysis because they did not experience any new RAS episodes during study participation.

痛みの強さも両者に差はなし。

 

マルチビタミンは、再発性アフタ性口内炎の再発を抑制しない。