甲状腺機能低下症の症候

J Clin Endocrinol Metab

 

. 1997 Mar;82(3):771-6.

 doi: 10.1210/jcem.82.3.3810.

Estimation of Tissue Hypothyroidism by a New Clinical Score: Evaluation of Patients With Various Grades of Hypothyroidism and Controls

H Zulewski ¹, B Müller, P Exer, A R Miserez, J J Staub

 

症候；

単独で感度の高いものはなし。

Table 1.

Sensitivity and specificity of the 14 symptoms and signs of hypothyroidism and analysis of their positive and negative predictive values

Symptoms and signs	Sensitivity (%)	Specificity (%)	Positive predictive value (%)	Negative predictive value (%)
Ankle reflex ；深部腱反射回復相遅延	77	93.5	92.2	80.3
Dry skin ；乾燥肌	76	63.8	67.7	72.7
Cold intolerancea ；寒がり	64	65	64.6	64.4
Coarse skin ；粗雑で厚い皮膚	60	81.2	76.1	67
Puffiness ；浮腫	60	96.3	94.2	70.7
Pulse ratea ；徐脈	58	42.5	50.2	50.3
Sweating ；発汗減少	54	86.2	79.6	65.2
Wt increase ；体重増加	54	77.5	70.6	62.8
Paraesthesia ；異常感覚	52	82.5	74.8	63.2
Cold skin ；冷えた皮膚	50	80	71.4	61.5
Constipation ；便秘	48	85	76.2	62
Slow movements ；動作緩慢	36	98.7	96.5	60.7
Hoarseness ；嗄声	34	87.5	73.1	57
Hearing ；難聴	22	97.5	89.8	52.6

 Two signs (cold intolerance and decreased pulse rate) showed positive and negative predictive values below 70% and were, therefore, excluded from the new score.

 

深部腱反射回復相遅延

発汗減少

乾燥肌

粗雑で厚い皮膚

冷えた皮膚

むくみ

体重増加

異常感覚

便秘

動作緩慢

嗄声

難聴

55歳以下の女性

の13項目中6項目の該当で、96.9%が甲状腺機能低下症；

感度62%・特異度99%

2項目以下で、94.2%が正常；

感度94%・特異度61%

 

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